Alexandre Lacazette late second half strike hands Arsenal an early advantage after beating host Olympiacos at the Stadio Georgios Karaiskáki in Greece.
Elsewhere at the Ludogorets Arena Italian side Inter Milan defeated Ludogorets 0-2 thanks to midfielder Christian Eriksen debut goal and Romelu Lukaka’s 95th minute penalty.
An early strike from January signing Carles Pérez was all AS Roma needed to edge pass Belgian side Gent at the Stadio Olimpico.
Anthony Martial cancelled out Denis Bonaventure 15th minute opener as both Club Brugge and Manchester United settled for a 1-1 draw to set up an interesting second leg at Old Trafford next thursday.
CFR Cluj – Sevilla 1:1
Club Brugge KV – Manchester Utd 1:1
Eintracht Frankfurt – Salzburg 4:1
FC Copenhagen – Celtic 1:1
Getafe – Ajax 2:0
Ludogorets – Inter 0:2
Shakhtar Donetsk – Benfica 2:1
Sporting – Basaksehir 3:1
APOEL – Basel 0:3
AS Roma – Gent 1:0
AZ Alkmaar – LASK 1:1
Bayer Leverkusen – FC Porto 2:1
Olympiacos Piraeus – Arsenal 0:1
Rangers – Braga 3:2
Wolfsburg – Malmo FF 2:1
Wolves – Espanyol 4:0